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Compliance with Ethics Guidelines The protocols for the PIONEER 15 and 8 trials were approved by independent ethics committees/institutional review boards at each trial site, and the trials were conducted in accordance with International Council on Harmonization Good Clinical Practice guidelines and the Declaration of Helsinki

The Category III codes for sacroplasty (0200T, 0201T) were updated to reflect that sacral vertebroplasty is now reported with a Category I code (22511, 22512), and the Category III codes are now used only to report sacral vertebral augmentation using a balloon or other mechanical device

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Louisans were among 573 survey respondents in 5 states: MO, NE, GA, MS and NC