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Common approaches include: Goal-based use: stop once a target weight is reached Maintenance use: continue at a lower or steady dose Long-term management: ongoing use for chronic weight control Your provider will help weigh benefits, side effects, and sustainability when deciding how long you should stay on semaglutide

Seek urgent medical attention if you experience: Severe, persistent abdominal pain (especially if radiating to the back) with or without vomiting, which could indicate pancreatitis Right upper quadrant pain, fever, or yellowing of the skin/eyes, which might suggest gallbladder disease Severe chest pain, difficulty breathing, facial swelling, or signs of an allergic reaction For urgent advice, call NHS 111

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Over the past few years, the key effects of gut microbiota on the regulation of serotonin level and function have garnered increasing attention