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PMID: 9387021
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Before agonist addition, the SNAP/FLAG-hGLP-1R signal was distributed across the plasma membrane and only weakly associated with clathrin-positive regions (F/S = 0.03 0.003 and 0.04 0.006 for WT and V229A, respectively), with no differences between WT and V229A receptors
However, their usefulness is limited by the risk of edema, heart failure, hepatotoxicity and possible cardiovascular effects[37]
