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Therefore, it is not clear whether GLP-1 RA directly improves mitochondrial function, reduces ER stress, and reduces neuroinflammation, or indirectly improves these mechanisms by lowering blood glucose and improving IR

The weight loss timeline with tirzepatide typically shows noticeable results within the first four to six weeks, with significant changes accumulating over three to six months

These numbers are meaningful for a population that traditionally struggles with weight management due to medications and disease activity

Mounjaro has the extra benefit of dual GLP-1 and GIP action, while Wegovy is solely a GLP-1 agonist