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For many patients, gastric sleeve is one of the strongest GLP-1 alternatives because it offers more durable weight loss, reduces hunger, and avoids the ongoing monthly cost of medication

The weekly injections are designed to be convenient, allowing patients to incorporate the treatment into their routine with minimal disruption

Berberine is found in plants and studies found people who took it saw decreases in body weight and BMI

This pattern reflects the chronic, relapsing nature of obesity and has prompted the WHO to recommend continuous, long-term treatment lasting six months or moreeffectively positioning these medications as lifetime therapies for many patients [51]