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n controlul greutii corporale, cel mai citat studiu este STEP 1 (Wilding i colab., 2021), de asemenea n NEJM, unde la aduli cu suprapondere sau obezitate (fr diabet), Semaglutide 2.4 mg o dat pe sptmn, n combinaie cu modificri ale stilului de via, a dus la o reducere clinic semnificativ i susinut a greutii pe parcursul a 68 de sptmni comparativ cu placebo