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National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases

If diarrhea occurs, ensure adequate hydration and electrolyte replacement

About TRIUMPH-4 and the TRIUMPH clinical trial program TRIUMPH-4 (NCT05869903) is a Phase 3, 68-week, randomized, double-blind, placebo-controlled study comparing the efficacy and safety of retatrutide with placebo in adults with obesity or overweight and knee osteoarthritis

Adverse side effects are one of the leading reasons individuals discontinue therapy or are unable to increase their dose, even if they havent yet reached their desired goals