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10.1186/s12974-017-0869-7 254

Some patients and clinicians prematurely conclude the medication is ineffective before reaching therapeutic doses of 10-15 mg weekly

[19] It is available on NHS prescription for adults with a BMI 28 kg/m (with risk factors) or 30 kg/m, alongside dietary and lifestyle measures

With intrinsic sympathomimetic activity (ISA) Pindolol Acebutolol Mechanism of Action Heart rate (negative chronotropy) Myocardial contractility (negative inotropy) AV nodal conduction Renin release from kidneys Overall: reduced cardiac workload and blood pressure Indications Cardiovascular Hypertension Ischemic heart disease (angina) Post-myocardial infarction Heart failure (metoprolol, bisoprolol, carvedilol) Arrhythmias (AF rate control, SVT) Non-cardiac Thyrotoxicosis Migraine prophylaxis Essential tremor Anxiety (performance anxiety) Portal hypertension (variceal bleed prophylaxis) Glaucoma (topical timolol) Adverse Effects Bradycardia Hypotension Fatigue Cold extremities Sexual dysfunction Sleep disturbances (esp