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Peptides and Mast Cell Activation: How GLP-1, GLP-2 and VIP Support the Nervous System in MCAS By Reine DuBois, Integrative Naturopath and Clinical Director The Health Lodge Understanding MCAS and Nervous System Involvement Mast Cell Activation Syndrome (MCAS) is a complex inflammatory disorder in which mast cells release excessive histamine and other mediators, causing symptoms that can affect every organ system

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The beneficial effects of GLP-1RAs are best understood via their ability to mitigate pathophysiological mechanisms of diabetes, such as systemic inflammation, oxidative stress, endothelial dysfunction and vascular fibrosis, which are key contributors to cerebrovascular disease [38]