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Mounjaro may work better for you if: Your primary goals include significant weight loss alongside blood sugar control You have not achieved target A1C levels with other GLP-1 medications Your healthcare provider recommends trying dual-action therapy You can tolerate the potentially stronger initial side effects Trulicity may suit you better if: You prefer a medication with a longer established safety record Your weight loss goals are modest You have achieved good results with GLP-1 medications previously You want to start with a medication your insurance readily covers Practical Tips for Success with Either Medication Regardless of which medication you choose in the Mounjaro vs Trulicity comparison, certain strategies help maximize your results and minimize discomfort