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FDA prescribing information for some GLP-1 receptor agonists advises considering discontinuation for sustained increases in resting heart rate

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Potential reasons for this include: (1) 79% of our patients used a GLP-1 RA for an indication of diabetes rather than weight management, and (2) interactions with breast cancer treatments such as chemotherapy, chemotherapy supportive medications such as steroids, and/or endocrine therapy, which exacerbate metabolic dysfunction and contribute to weight gain, may attenuate weight loss with a GLP-1 RA