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[1] [2] These symptoms typically occur during dose initiation or escalation and often improve over time as the body adjusts to the medication

Lancet (London, England) 2017;390(10113):26272642

Most patients find that gastrointestinal side effects improve significantly after the first 24 weeks of treatment, and the benefits of the medication become more apparent as tolerance develops

On GLP-1 therapy, that usually feels uncomfortable and still leaves protein intake short