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Monotherapy with GLP-1 receptor agonist, lixisenatide, significantly improves glycaemic control in type 2 diabetic patients [abstract 830]

Retatrutide activates three separate receptor pathways simultaneously: GLP-1 for appetite suppression, GIP for enhanced fat oxidation and tolerability, and glucagon for increased energy expenditure

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Real-world evidence from observational studies consistently shows that GLP-1 RA use is associated with reduced risk of hepatic decompensation even in patients with established cirrhosis, supporting cautious use in this population