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Questions to ask your care team about using semaglutide for weight loss include: Is it safe to take semaglutide for weight loss

It was soon demonstrated that leaks in the blood barrier notably in the area postrema, the subfornical organ and the median eminence would not only allow entry of GLP-1 into these regions of the brain (87), but there was also dense receptor expression at these sites suggesting peripheral GLP-1 might also have actions on the brain (80), and in 1998 it was demonstrated that peripheral intravenous infusions of physiological amounts of GLP-1 would lead to decreased appetite and inhibition of food intake (88)

Clinical trials have shown impressive results, with participants losing an average of up to 23.6 kg (52.0 lbs) over 72 weeks at higher doses

Absorption, distribution, metabolism, and excretion of tirzepatide in humans