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However, GLP-1s can come with challenges, including gastrointestinal side effects, risk of micronutrient deficiencies, muscle and bone loss, poor long-term follow through with weight regain if stopped, and high costs

doi: 10.1038/S41598-019-55524-W 116 O'NeilPMBirkenfeldALMcGowanBMosenzonOPedersenSDWhartonSet al

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The cardiovascular benefits, demonstrated in the SELECT trial showing reduced heart attack and stroke risk with semaglutide, actually argue in favor of continued use for people with cardiovascular risk factors