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Description
Preproglucagon neurons projecting from the NTS carry GLP-1 to other areas of the brain that induce satiety including critical areas of the hypothalamus

At 48 weeks, 64 to 100% of participants in the retatrutide groups had body-weight reductions of 5% or more, as compared with 27% of the participants in the placebo group
As shown in Scheme 5
Contributions of fasting and postprandial plasma glucose increments to the overall diurnal hyperglycemia of type 2 diabetic patients: variations with increasing levels of HbA(1c)