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Indications Treatment of type 2 diabetes Individual patient-oriented treatment which needs re-assessment in every 36 months, is being advocated by American Diabetes Association 2020 and the Management of Hyperglycaemia in type 2 diabetes by European Association for the Study of Diabetes consensus report 2019 [80, 81]

Increased blood pressure inhibits water intake (33), but the time course of the pressor response to GLP-1 and the suppression of intake do not support changes in blood pressure as a more direct cause of the observed effects on water intake

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While findings are promising, the benefits of GLP-1RAs remain hypothesis-generating, and prospective randomized trials are needed to determine causality, optimal use, and underlying mechanisms