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Fixed-dose combination means less flexibility in dosing

[DOI] [PubMed] [Google Scholar] [27].Zhu DD, Zhang XP, Zhang BL, Hao YY, Guo XD, Safety Assessment of Microneedle Technology for Transdermal Drug Delivery: A Review, Advanced Therapeutics 3(8) (2020) 2000033
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Generally, this ECD conformation can be acquired by rotating the ECD roughly 30 horizontally from its position in the crystal structure (Fig