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Accordingly, preclinical research has established crucial mechanisms of neurotransmission within the reward system that differentiate between motivational aspects of reward (i.e., dopamine) rather than the pleasure (i.e., opioids and endocannabinoids) itself (Berridge & Kringelbach, 2015
The general recommendation is to use one medication at a time and its advisable to consult with a healthcare professional before considering a combination of these medications

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The PhD scientist must assess whether a prior art reference teaches the claimed invention with enough specificity to support an obviousness challenge, because patent attorneys without deep technical backgrounds frequently underestimate or overestimate that risk
