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GLP-1 acts on the GLP-1R, activating multiple intracellular signaling pathways, including the cAMP/PKA pathway, the PI3K/Akt signaling pathway, and pathways related to anti-inflammatory and anti-oxidative stress responses, among others

Asterisks indicate a statistically significant difference by 1-way Welchs ANOVA with Games Howell post hoc test

Am J Physiol (1996) 271:E45864

Numerous TNF- inhibitors have been investigated in rat models of central nervous system disorders and have been shown to boost cognitive performance, preserve synapses, reduce apoptosis, promote neuronal survival, and minimize neuroinflammation (Chen et al