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Conversely, those with lower-sensitivity variants may reach therapeutic weight loss at lower doses, potentially reducing cumulative exposure and any bowel-related side effects

There are many potential/partial explanations for this difference: Tirzepatide is a dual agonist (for GIP/GLP-1), making it an arguably more structurally complex molecule and less tenable for recombinant expression (though both are linear peptides with a side chain)

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Novel therapies with precision mechanisms for type 2 diabetes mellitus