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Ultimately, these numbers do not suggest that FDA oversight is failing

In 2014, the Stimulation Therapy for Apnea Reduction (STAR) trial found that, among patients with moderate-to-severe OSA and a body mass index (BMI) of less than 32 kg/m 2 , unilateral hypoglossal nerve stimulation led to a 68% reduction in OSA severity (based on AHI) at 12 months, and improvements in sleepiness scores [44]

The improvement in LDL particle size is particularly relevant, as smaller, denser LDL particles are more strongly associated with an increased risk of atherosclerotic cardiovascular disease compared to their counterparts [13]

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