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Generics for leading GLP-1 products are still more than five years away, so weight loss and GLP-1 treatments are likely to remain costly in the near-term

This underscores the importance of long-term treatment planning and building sustainable lifestyle changes alongside medication use (Wilding et al., 2022)

This limitation is, however, mitigated by the recent findings of Lamont et al [8] who, using transgenic overexpression of Glp1r in beta cells of Glp1r- null mice, clearly established the critical role of the beta cell GLP-1 receptor (GLP1R) in mediating the beneficial effects of GLP-1 on glucose homeostasis