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Though microglial activation does have essential housekeeping roles such as removing neuronal cell debris, the chronic overactivation of microglia can cause overproduction of the pro-inflammatory cytokines and dopaminergic neuron degeneration (Ferrari et al., 2006
Forest plot of the meta-analysis for the SGLT2i comparison using the more sensitive NAION definition
The changes in HDL-C, triglycerides, and total cholesterol were similar in STEP-1 and SELECT, and there remained a significant decrease in LDL-C even though patients started at a lower LDL-C level [33, 48]
