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Retrieved from NCBI Bookshelf: (Comprehensive overview of indications, mechanism of action for methemoglobinemia, dosing, and safety considerations for methylene blue)
Split dosing becomes valuable when single dosing produces inconsistent results, when doses above 400mcg are needed, or when evening administration fits better into lifestyle patterns
The best shake is one you actually finish
The success of both compounds, using different combinations of the same three receptor targets, has validated the multi-agonist approach and opened the door for even more combinations
