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Patients with a personal or family history of diabetic retinopathyespecially those with preexisting vision changesneed ophthalmologic clearance, because rapid weight loss and improved glycemic control can sometimes worsen retinopathy temporarily in susceptible individuals

Patients entered a run-in treatment period on glimepiride (4 mg per day) alone or glimepiride in combination with metformin HCl (1500 mg per day)

Cholelithiasis in patients treated with glucagon-like Peptide-1 receptor: an updated meta-analysis of randomized controlled trials

It carries minimal hypoglycemia risk and benefits cardiovascular outcomes in some populations