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These findings suggest GLP-1 acts directly on the hypothalamic feeding centers
It's also worth noting if a medication is approved by the FDA for weight loss specifically, as this often plays a big role in coverage decisions
In the retatrutide trials, the ratio of fat loss to lean loss was favorable compared to caloric restriction alone, where lean mass can represent 25-35% of total weight lost
Mounjaro Ph3 trial SURMOUNT showed 95.3% of patients on Mounjaro with prediabetes at baseline reverted to normogylcemia by week 72
