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Additionally, we found that mog mutants exhibit overexpression of che-13 and loss of che-13 nearly completely rescues the shortened lifespan of mog mutants

49 It is interesting that the double Aib substitutions led to comparable receptor binding and potency (IC 50 = 1.1 nM, EC 50 = 0.06 nM compared to GLP-1 (IC 50 = 1.5 nM, EC 50 = 0.08 nM)), whereas a single Aib at position 8 brought in a 4-fold decrease in potency and 2-fold increase in binding affinity

The results revealed a clean, linear dose-response curve where each step up delivered roughly three additional percentage points of weight loss

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