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however, gastrointestinal adverse effects such as nausea, vomiting, and diarrhea are the most frequently reported, particularly during the initial treatment phase ( Additionally, weight loss with GLP-1 RAs is accompanied by reductions in lean mass, with skeletal muscle accounting for approximately 15%40% of total weight loss ( 6 Conclusion and future directions The data strongly supports that SLD, is fueled by common pathways of altered metabolism and chronic inflammation, which are the central precipitating factors for HCC development across MASLD, ALD, and to some extent, chronic viral etiologies

T3 directly regulates hair follicle cycling, and even subclinical thyroid dysfunction, levels that fall within the "normal" range but sit at the lower end, can push follicles into premature telogen

In regard to medical therapy before treatment initiation, GLP1 RA initiators more often redeemed prescriptions for mineralocorticoids, betablockers, calcium channel blockers, reninangiotensin system inhibitors, loop diuretics, and thiazides, but less often for acetylsalicylic acids and statins, compared with metformin initiators

Lancet Diabetes Endocrinol 7(7):549559 Hany M et al (2024) Boosting weight loss after conversional Roux-en-Y gastric bypass with liraglutide and placebo use