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Adverse Reactions in Patients for Weight Reduction and Long-Term Maintenance Pool of Placebo-Controlled Weight Reduction Trials in Adults with Obesity or Overweight, with or without Type 2 Diabetes (Study 1 and Study 2) ZEPBOUND was evaluated for safety in a pool of two randomized, double-blind, placebo-controlled trials that included 2,519 adult patients with obesity or overweight treated with ZEPBOUND for up to 72 weeks and a 4-week off drug follow-up period (Study 1 and Study 2) [see Clinical Studies (14.1)]

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In accordance with American Society for Reproductive Medicine (ASRM) guidelines, referral to a reproductive endocrinologist may be appropriate after 12 months of attempting conception for women under 35 years, after 6 months for women 35-39 years, and earlier for women 40 years and older or those with known risk factors such as irregular menstrual cycles, PCOS, tubal disease, endometriosis, or male factor infertility