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This data can support more informed conversations about whether a lower-cost option like oral semaglutide might work well for your genetic profile, or whether a higher-potency drug like tirzepatide offers better value given your metabolic predispositions

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In a smaller cohort of patients with more severe CD phenotypes, including 17% with perianal involvement and 24% with penetrating or fistulizing disease, numerical reductions across outcomes were observed in the GLP-1RA group, but these differences did not reach statistical significance (104)