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Description
Semaglutide activates the GLP-1 receptor (GLP-1R), a class B G-protein-coupled receptor expressed in pancreatic beta cells, the hypothalamic arcuate nucleus, the area postrema, the nucleus tractus solitarius, and vagal afferent neurons

may escalate to 1 mg or 2 mg weekly based on response

doi:10.1016/s0021-9258(18)32858-8 26 BellGISanchez-PescadorRLaybournPJNajarianRC

Legal and common, but may affect insurance coverage
