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Ma EJ, Roberts AM, Chou P, Katz A, Jeong CY, Nong Y, et al
dual-pathway options include tirzepatide) mimic natural gut hormones that signal fullness and steady blood sugar
79 Inhibition of hepatic gluconeogenesis is thought to be the primary means by which metformin exerts its effects on glucose homeostasis

These medications also decelerate the transit of food from the stomach to the small intestine, leading to a sensation of prolonged fullness
