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Importantly, although their glucose-lowering efficacy diminishes in advanced CKD, cardiovascular and kidney benefits remain preserved [111]

Neurobiology of addiction: a neurocircuitry analysis

An exploratory mediation analysis of the effects on kidney outcomes (composite of macroalbuminuria, decreased GFR, renal death) with liraglutide and semaglutide in patients with T2DM in the LEADER and SUSTAIN-6 trials observed that HbA1c mediated 2526% and SBP 922% of kidney effects with a negligible contribution of the other parameters studied, such as body weight [15]

All formulas used for imputing the missing values were provided in the Cochrane Handbook for Systematic Reviews of Intervention (Version 6.5, Section 6.5.2.8)