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Receptor agonists include full agonists, partial agonists, and inverse agonists

GLP-1 receptor agonists are synthetic molecules that mimic the binding of glucagon-like peptide-1 (GLP-1), a hormone that helps our bodies regulate metabolism and appetite

The reduced expression of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) by GLP-1 agonists decreases monocyte attachment to endothelial cells, thus preventing the initial process of atherogenesis in ApoE-knockout mice [9,24]

Figure 16: Painting of Professor John C Brown (19382016) by his grandson, Matthew T Kieffer, credit: Kieffer