![step semaglutide Change in body weight with 2.4 mg: trials [95–98] Once-weekly semaglutide 7·2 mg in](https://www.researchgate.net/publication/377114282/figure/fig2/AS:11431281215640943@1704338910350/Change-in-body-weight-with-semaglutide-24mg-STEP-trials-95-98.png)
step semaglutide Change in body weight with 2.4 mg: trials [95–98] Once-weekly semaglutide 7·2 mg in
Description
This has led many patients to seek treatment through private prescribing, where eligibility criteria may differ and access is faster, albeit at personal cost
![step semaglutide Change in body weight with 2.4 mg: trials [9598] Once-weekly semaglutide 72 mg in](https://www.thelancet.com/cms/10.1016/S2213-8587(25)00226-8/asset/fd74d5b9-b94f-420a-ba3e-9f0baf1be2f1/main.assets/gr2_lrg.jpg)
Semaglutide activates only the GLP-1 receptor, while tirzepatide activates both GLP-1 and GIP receptors, which may lead to slightly greater weight loss in some patients
![step semaglutide Change in body weight with 2.4 mg: trials [9598] Once-weekly semaglutide 72 mg in](https://framerusercontent.com/images/vA1tAzobDb1yLeajs5cs1priCU.png)
Serious Side Effects In rare cases, semaglutide can cause more serious side effects, like: Pancreatitis Kidney problems Gallbladder disease Thyroid tumors (observed in animal studies) Managing Side Effects Common side effects are mild and inclined to reduce over time as the body regulates according to the medication
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