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scenarios where the magnitude of effect is critical and 15-20% body weight reduction is medically necessary
The previous reports of multiple beneficial effects of orally administered d-allulose prompted us to infer that it might act through stimulating GLP-1 release and/or vagal afferent signaling, both of which transmit gut signals to remote organs including the brain
In rodents with 6-OHDA and ROT-induced lesions, GLP-1R was associated with increased expression of B-cell lymphoma-2 (Bcl-2) and complex I and reduced expression of caspase-3, halting cell death [82,83]
Maintained for the next 3 years
