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Many people feel unwell with a TSH of 4.0 to 5.0, even though its technically normal. Optimal thyroid function involves: TSH is between 0.52.5 mIU/L (some doctors and patients prefer a level below 2.0) Free T4 is in the upper half of the reference range Free T3 is in the upper half of the reference range Low or absent symptoms of hypothyroidism, such as fatigue, hair thinning, constipation, cold intolerance, or depression In autoimmune thyroid disease (Hashimotos), its also helpful to monitor thyroid peroxidase (TPO) antibodies and support the immune system with selenium, vitamin D, and lifestyle changes to reduce inflammation

Because retatrutide acts on three receptors, some researchers call it a triple agonist. This design may explain why trial results gained so much attention

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Many patients who stop taking it tend to gain back weight or lose the health benefits they had achieved