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Dr Alison Cave, MHRA chief safety officer, said that new medicines, such as tirzepatide, are more intensively monitored to ensure any new safety issues are identified promptly

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A 2025 network meta-analysis ranked nausea risk as follows: orforglipron (highest, relative risk 4.77), liraglutide (3.09), semaglutide (2.94), tirzepatide (2.89), exenatide (2.66), and cagrilintide (2.29)

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