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Adding it to the mix might create yet another additive or synergistic benefit

on December 19, 2015

3739 While it is encouraging that the weight loss achieved with GLP-1/GIPGLP-1 receptor agonists approaches levels typically seen after bariatric procedures such as gastric bypass or sleeve gastrectomy, the rapid regain of a significant portion of the lost weight after treatment discontinuation, accompanied by a reduction in lean body mass, raises new clinical concerns

191 The mechanism of GLP-1 RA to improve dopaminergic degeneration and pathological -synuclein aggregation in the PD model may involve inhibiting the PI3K/Akt/mTOR pathway 192 and enhancing AMPK/PGC-1a signaling pathway