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In early 1987, Mojsov, Weir, and Habener tested the insulinotropic effect of GLP-1(7-37) in the isolated rat pancreas and found it potently stimulated insulin secretion six-fold at a physiologic concentration of 5 10 11 corresponding well to its circulating levels (9)
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According to Clark et al., 82 an increase in the ratio of omega-6 to omega-3 fatty acids contributes to obesity rates by increasing the levels of endocannabinoid N -arachidonoylethanolamide (or anandamide) and 2-AG, overstimulating CB1 and leading to increased caloric intake, reduced metabolic rates, and weight gain
10.1016/j.regpep.2004.08.024 68
