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Oral semaglutide vs sitagliptin: efficacy by baseline HbA1c and background OAD in PIONEER 3
[33] first documented a reduced incretin effect in patients, with type 2 diabetes
For instance, in 3xTg-AD mice, sex-specific alterations in brain bioenergetics have been observed: females showed impaired complex I activity in synaptic cortical mitochondria, while non-synaptic mitochondria exhibited enhanced complex IImediated respiration (Stojakovic et al., 2021)
As weve noted, severe complications affecting the GI tract could prove fatal if they are not dealt with in a timely manner
