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GLP-1 analogs are very popular, but although most insurers cover them as a treatment for uncontrolled diabetes, very few commercial health plans cover them for weight loss

L., et al., Vildagliptin, a Dipeptidyl PeptidaseIV Inhibitor, Improves ModelAssessed Cell Function in Patients With Type 2 Diabetes, Journal of Clinical Endocrinology and Metabolism 90, no
swelling of the face, lips, tongue, or throat

That is a clinically significant reduction, comparable to what you would expect from a dedicated blood pressure medication