abbvie glp-1 receptor agonist weight management diabetes treatments How Agonists Evolved from to Loss GLP−1 receptor agonists for the

Abbreviations: VTA: ventral tegmental area, NAc: nucleus accumbens, NTS: nucleus tractus solitarius, LH: lateral hypothalamus, DMHipp: dorsomedial hippocampus, LDTg: laterodorsal tegmental nucleus, LS: lateral septum, CeA: central amygdala, PVN: paraventricular nucleus, DA: dopamine, : decreased, : increased, MAO-A: monoamine oxidase A, COMT: catechol-O-methyltransferase, D1-MSN: D1-type medium spiny neuron, OX1R: orexin-1 receptor, HPA: hypothalamicpituitaryadrenal axis

Diabetes: From Research to Clinical Practice

doi: 10.1177/20420188231222367 11 MadsenMSAHolmJBPallejAWismannPFabriciusKRigboltKet al

2 Although the pancreatic effects of GLP-1 (glucose-dependent insulin secretion and glucagon suppression) are well-established, its extrapancreatic actions are increasingly being recognised as critical to the therapeutic effects of GLP-1RAs