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Lancet Diabetes Endocrinol 7(10):776785 Muskiet MHA, Smits MM, Morsink LM, Diamant M (2014) The gutrenal axis: do incretin-based agents confer renoprotection in diabetes

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Collectively these data cast doubt as to the contribution of inhibition of complex 1 as the primary target and explanation for the therapeutic effects of metformin both as an anti-diabetic and as an anti-aging drug

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