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John Eng, working at the Veterans Administration Center in the Bronx, identified a peptide in Gila monster venom he called exendin-4

Archived from the original on 5 March 2021

In preclinical models, comparison of cotadutide, a glucagon/GLP-1 dual RA, and liraglutide demonstrated superior reduction of hepatic de novo lipogenesis and enhancement of hepatocyte mitochondrial oxidative capacity (similar to levels stimulated by glucagon mono-agonismsuggesting restoration of mitochondrial function is a glucagon-specific benefit) [39]

This article is based on previously conducted studies and does not contain any new studies with human participants or animals performed by any of the authors