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[2] Women with pre-existing PCOS, previous menstrual irregularities, or those who have lost more than 10% of their body weight rapidly should have a lower threshold for seeking review

This approach works for weight loss but fails for body composition

Dosage escalation is designed to minimize side effects: Wegovy: Start at 0.25 mg weekly, gradually increase every 4 weeks until the maintenance dose of 2.4 mg is reached
