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Bolli et al demonstrated significant weight loss with lixisenatide after 24 weeks as compared to placebo (1.1 to 1.0 kg least squares mean difference

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They explain in an editorial for the South African Medical Journal that evidence shows, that on their own, recommendations for diet and exercise are unable to combat obesity and contribute to societal stigma and individual shame

Food intake was recorded every 48 h (accounting for crumb spillage) beginning at dark cycle onset