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An albumin engineering strategy (QMP) compensates for the poor PK properties resulting from cleavage, as demonstrated for a GLP-1 albumin fusion

Mechanistically, we identify a subset of Glp1r -expressing neurons in the dorsal vagal complex that, upon semaglutide treatment, regulate genes involved in anti-inflammatory signaling

Both are excellent once weekly injections, but they aren't quite the same medication. Wegovy contains semaglutide and works on GLP1 alone, with an average weight loss of around 15% in trials. Mounjaro contains tirzepatide and works on two hormones (GLP1 and GIP), with an average weight loss of 22.5%. Wegovy starts from 99.99 a month and Mounjaro from 164.99. Your clinician will help you decide which is the better fit for your goals, medical history, and budget
