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Second, head-to-head comparative trials between GLP-1 RA monotherapy, dual agonists, and triple agonists in MASH populations with histological endpoints are entirely lacking: current selection among agents relies on indirect comparisons across trials with different inclusion criteria and follow-up periods
However, the relationship between improved glycemic control and cognitive function is complex, as demonstrated by mixed results in large trials like ACCORD-MIND
Even our template option includes patient-specific clinical context and structured arguments
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